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CAESAR (connectomics and electrical stimulation for augmenting resection) is our exciting new study in collaboration with The Brain Tumour Charity. It involves combining state of the art connectome based brain mapping and intra-operative neurophysiological recordings with awake brain stimulation.

Patients will be invited to participate depending on individual imaging and clinical characteristics. The main criteria are a tumour with features consistent with a low grade glioma on MRI scanning and that is planned to be removed surgically using awake brain mapping (otherwise known as awake brain stimulation).

A full information pack will be given during the initial clinic visit. For more information, download a brief presentation on the methods and science:

CAESAR introductory presentation

Below is a flow chart of the study protocol:

Here is a brief overview of the study: participants recruited to the study will be informed about the study in detail, in person, and supplemented with detailed written guidance. Eligible participants will be invited to take part at their first neurosurgery clinic visit. After that participants will have their routine pre-operative assessment as usual, but an additional research MRI scan will be performed. Surgery will then be performed as normal with awake brain mapping, but in this case we will use special sheets of electrodes to record the brain's activity. Finally, participants will recover from surgery as normal, and then undergo routine follow-up assessments. The only difference with the research study is we will perform an additional MRI scan at each follow-up assessment, and the neuropsychological data we record to monitor recovery will be analysed in more detail. The aim of this study design was to maximise the amount of information we could acquire while minimising the burden of extra assessments for the participants.